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. 2021 Sep 24;26(19):5782. doi: 10.3390/molecules26195782

Table 1.

Structure and activity of NSAIDs-derived chloropyridinyl esters.

No. Compound Structure SARS CoV-2
3CLpro IC50 (µM)		 SARS-CoV-2
EC50 (µM) a
1 graphic file with name molecules-26-05782-i001.jpg 0.36 >100
2 graphic file with name molecules-26-05782-i002.jpg 0.67 >100
3 graphic file with name molecules-26-05782-i003.jpg 0.16 >100
4 graphic file with name molecules-26-05782-i004.jpg 0.81 >100
5 graphic file with name molecules-26-05782-i005.jpg 5.32 30.2

a Compounds 3 and 5 exhibited antiviral EC50 values of 2.8 and 2.4 μm, respectively.