Skip to main content
. 2021 Sep 24;26(19):5782. doi: 10.3390/molecules26195782

Table 2.

Structure and activity of salicylic acid and its substituted chloropyridinyl esters.

No. Compound Structure SARS CoV-2
3CLpro IC50 (µM)		 SARS-CoV-2
EC50 (µM) a
1 graphic file with name molecules-26-05782-i006.jpg 3.47 >100
2 graphic file with name molecules-26-05782-i007.jpg 17.1 63.7
3 graphic file with name molecules-26-05782-i008.jpg 0.65 >100
4 graphic file with name molecules-26-05782-i009.jpg 4.9 23.8
5 graphic file with name molecules-26-05782-i010.jpg 0.54 >100
6 graphic file with name molecules-26-05782-i011.jpg 1.4 >100
7 graphic file with name molecules-26-05782-i012.jpg 0.39 46.3
8 graphic file with name molecules-26-05782-i013.jpg 0.74 48.3
9 graphic file with name molecules-26-05782-i014.jpg 3.73 >100
10 graphic file with name molecules-26-05782-i015.jpg 4.26 >100
11 graphic file with name molecules-26-05782-i016.jpg 15.4 >100
12 graphic file with name molecules-26-05782-i017.jpg 107.8 >100
13 graphic file with name molecules-26-05782-i018.jpg 1.11 >100
14 graphic file with name molecules-26-05782-i019.jpg 1.51 >100

a Compounds 3 and 5 exhibited antiviral EC50 values of 2.8 and 2.4 μm, respectively.