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iNOS expression and related pathways. The expression of iNOS is regulated by cytokines and other factors. Factors that decrease iNOS expression include those such as the tumor suppressor, p53, as well as proteins (e.g., TGF-β) that inhibit the activity of NF-κB. On the other hand, proteins that activate iNOS such as STAT1, IFNγ, or nuclear factor-κB (NF-κB), increase the production of NO.
