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The direct and indirect impact of NO on IRP1 and IRE-binding. In the presence of NO, two mechanisms result in the loss of the [4Fe-4S] cluster: (a) direct attack of NO inducing disassembly of the cluster; and (b) an indirect mechanism where NO binds intracellular iron to induce its release from cells, resulting in iron depletion that therefore prevents [4Fe-4S] cluster biogenesis.
