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. 2021 Sep 25;26(19):5803. doi: 10.3390/molecules26195803

Figure 1.

Figure 1

Immune response dysregulation induced by SARS-CoV-2 in severe COVID-19. Legend: (A) Respiratory epithelial cells; (B) Resident macrophages; (C) Blood-recruited neutrophils; (D) Monocyte-derived macrophages. Abbreviations: ACE = Angiotensin Converting Enzyme; PRRs = Pattern Recognition Receptors; NF-κB = Nuclear Factor-κB; IRF = Interferon Regulatory Factor; IFN = Interferon; IL = Interleukin; TNF = Tumor Necrosis Factor; CCL = C–C motif Chemokine Ligand; CXCL = C–X–C motif Chemokine Ligand.