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. 2021 Sep 24;26(19):5790. doi: 10.3390/molecules26195790

Figure 1.

Figure 1

Unilateral DA lesion by 6-OHDA produces a contralateral forelimb stepping deficit. (A) Forelimb stepping scores (mean ± SEM) in tests performed pre- and four weeks post-surgery. These tests revealed that the 6-OHDA lesion produced a stepping deficit in the forelimb contralateral to the lesion, while stepping with the ipsilateral (intact) forelimb was not affected. The stepping scores given are from the included animals that showed three or fewer adjusting steps with the contralateral forelimb (n = 33). (B) Number of TH-positive cells in the SNc ipsilateral to the lesion, expressed as percentage of the TH-positive cells on the intact side. The included animals displayed a loss of 87.9–98.6% of TH-positive (DA) neurons on the side of the lesion (mean ± SEM, 93.95 ± 0.72% of intact side).