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. 2021 Sep 2;28(11):2483–2501. doi: 10.1093/jamia/ocab151

Table 2.

Study characteristics

Study Study design Age (range, mean) Gender
(female)
Education
(college degree or higher)
Computer-related experience Sample size Country Application descriptions Health domain
Disease prevention and self-management (N = 28)
Alsswey et al25 Quantitative research (Survey)

60+,

Mean (M): not reported.

15.70% 23.90% All had at least 1 year of experience in using mobile applications. 134 Not reported A mobile app designed to manage physical health needs for Arab elderly users (eg, medication-related information and instructions) Medication adherence
Alvarez et al26

Quantitative research

(Pilot study: usability study, feasibility study)

Usability: 65+, M = 73.2;

Feasibility: 65+, M = 76

Usability: 67.6%; Feasibility: 59.5%

Usability: 9 years of education;

Feasibility: 10.53 years of education

Usability: 32.3% had previous experience with technology. Usability: 34; Feasibility: 62 Chile A mobile app that provides interventions to prevent delirium for bedside use for hospitalized elderly patients Delirium prevention
Bakogiannis et al27 Quantitative research (Usability study, pilot study)

Usability: M = 64.9;

Pilot: M = 68.7

Usability: 21%;

Pilot: 13%

Not reported. Not reported.

Usability: 14;

Pilot: 30

Greece ThessHF app, a mobile app that supports heart failure self-care for elderly patients with heart failure Heart failure self-management
Balsa et al28 Quantitative research (Usability study) 67–80, M = 70.91 72.2% 63.6% Not reported. 11 Portugal VASelfCare, a mobile-based intelligent assistant (in the form of an anthropomorphic virtual assistant) that supports older adults with Type 2 Diabetes Mellitus (T2DM) in medication adherence and lifestyle changes T2DM self-management
Baric et al29

Qualitative research

(Focus groups)

66–85, M = 73 45% 40% 55% had daily or weekly computer use; 85% had daily or weekly phone use. 20 Sweden RemindMe, an interactive digital calendar that provides active reminders for senior people with cognitive impairment Cognitive impairment self-management
Chen et al30

Qualitative research

(Usability study)

64 100% Not reported. Not reported. 1 China Win-Win aSleep (WWAS), a mobile app to assist cognitive behavioral therapy for older adults with insomnia Insomnia self-management
Chen et al31

Quantitative research

(Pre-post intervention study)

60+,

M = 86.68

77% Not reported. Not reported. 57 Hong Kong Lok Chi, a home-based tablet-based intervention designed to improve cognitive and emotional health for community-dwelling older adults with mild cognitive impairment (MCI) MCI self-management
Chung et al32

Quantitative research

(Pre-post intervention study)

65–78,

M = 71.56

100% 0%

38 had Android smartphones; 2 had feature phones on which mobile apps were not available.

40 South Korea MIND MORE, a mobile app for insomnia self-management in community-dwelling older adults Insomnia self-management
Cunningham et al33 Quantitative research (Cohort study) 69–97, M = 84.6 64% Not reported. Not reported. 14 United Kingdom Memory Tracks, a music mobile platform that provides song-task association training for elderly people with dementia Dementia self-management
Djabelkhir et al34

Quantitative research

(RCT)

60+,

M = 79

60%–70% 44.4%–60% Not reported 14 France Two tablet-based cognitive training apps (cognitive stimulation, cognitive engagement) for elderly patients with MCI MCI self-management
Fortuna et al35 Quantitative research (Feasibility study)

60+,

M = 68.8

87.50% 12.50% 62.5% had smartphones. 8 United States PeerTECH, a tablet-delivered psychiatric self-management intervention for older adults with mental illnesses Psychiatric self-management
Hackett et al36

Quantitative research

(Pilot study, within-subject, cross-over experiment)

65+,

M = 80.3

70% Not reported. Participants were able to use computers and had positive attitudes toward computers. 10 United States SmartPrompt, a mobile reminder app for older adults with dementia and MCI Self-management of dementia and MCI
Holden et al37 Quantitative research (Usability study) 60–85, M = 67.6 61.00% 23.00% Some participants had never used a smartphone before. 23 United States Brain Buddy, a mobile app to reduce unsafe medication use by older adults Medication use
Jongstra et al38

Quantitative research

(RCT)

65+,

M = 69

56% 29% Not reported. 41 Finland, France, The Netherlands An interactive counseling platform for healthy aging (ie, cardiovascular risk profiling and prevention) Cardiovascular diseases prevention
Jung et al39

Qualitative study

(Usability study, interviews)

65–80,

M: not reported.

78.57% 57.14% All participants had experience with smartphones. 14 United States FRADA, a food record app that provides dietary assessments for older adults with Type 2 Diabetes Diabetes self-management
Kim et al40

Mixed methods research

(Pilot study)

65+,

M = 75.7

91% 18.2% Participants had 3.5 years of smart device usage experience on average. 11 South Korea 365 Healthy Swallowing Coach, a mobile app that delivers swallowing training for elderly dysphagia patients Swallowing training
Loh et al41

Mixed methods research

(Pilot study)

68–87, M = 76.8 17% 67% 44% (17%) had access to a mobile phone (a tablet or iPad). 18 United States TouchStream, a mHealth app that provides geriatric assessment-driven interventions for older adults with cancer Cancer treatment
Madill et al42 Quantitative research (Usability study)

60+,

M = 75.5

23.30% Not reported. Not reported. 30 United States “Take Back Your Back”, an iPad-based educational tool for older adults with chronic lower back pain Back pain treatment
Manca et al43 Quantitative research (Between-subject experiment)

69–84,

M = 75.3

64.3% 7.14% 50% were familiar with technologies and devices. 14 Italy A music-based game (robot version and tablet version) for older adults with MCI MCI self-management
Manera et al44

Quantitative research

(Pilot study)

60–90, M = 78.3 71% Not reported. Not reported. 21 Not reported. “Kitchen and cooking”, a tablet-based serious game for elderly people with MCI and Alzheimer’s Disease (AD) Self-management of MCI and AD
Mertens et al45 Quantitative research (Crossover design)

60+,

M = 73.8

50% 25% 16.7% expert in computer literacy 24 Germany Medication Plan, a mobile app designed to improve therapy adherence for elderly patients undergoing rehabilitation Rehabilitation self-management
Mira et al46

Quantitative research

(RCT)

65+,

M = 72.9

Not reported. Not reported. 45% had smartphone experience. 99 Spain ALICE, a tablet-based app for medication self-management Medication self-management
Portz et al47

Quantitative research

(Pilot study)

60+,

M = 66

60% Not reported. Not reported. 30 United States HF app, a mobile app that tracks heart failure symptoms in elderly users Heart failure self-management
Puig et al48

Quantitative research

(RCT)

60+,

Median = 66

28% Not reported. Not reported. 100 Finland +Approp, a mobile app for HIV prevention and self-management for older HIV-infected patients HIV prevention and self-management
Quinn et al49

Quantitative research

(Pilot study)

65+

M = 70.3

57% Not reported. 71.4% had Internet at home. 7 United States Patient coaching system (PCS), a mobile software for diabetes management for older adults Diabetes management
Reading Turchioe et al50 Quantitative research (Feasibility study)

60+,

M: not reported.

37% 47% 30.4% did not have a computer and 26.2% did not have the internet. 168 United States mi.Symptoms, a mobile app that facilitates symptom reporting and patient outcome reporting in older adults Chronic disease self-management
Scase et al51

Qualitative research

(Focus groups)

65–80, M = 75.0 88% Not reported. Not reported. 25 United Kingdom 4 tablet-based cognitive games (ie, “Find it,” “Match it,” “Solve it,” and “Complete it”) for older adults with mild cognitive impairment MCI self-management
Sun et al52

Quantitative research

(RCT)

66–72

M = 68

59.34% Not reported. Not reported. 91 China A mobile-based telemedicine app for T2DM self-management for older adults T2DM self-management
Physical and cognitive function improvement (N = 27)
Albergoni et al53

Quantitative research

(Pilot study)

70–78,

M = 73.8

40% Not reported. Not reported. 10 The Netherlands PACE, a mobile app that visualizes user adherence to physical activity programs Physical activities
Baez et al54

Quantitative research

(RCT)

65–87, M = 71.5 70%–75% Not reported. Not reported. 40 Italy Gymcentral, a tablet-based app for home-based online group exercises under the supervision of a human coach Home-based exercises
Bergquist et al55

Mixed methods research

(Usability study)

60–80, M = 66.4 48% Not reported. 83% had mobile experience. 343 Norway, Germany, The Netherlands 3 mobile apps that deliver physical function self-tests (ie, Self-TUG, Self-STS, Self-Tandem) for older adults Physical function self-tests
Compernolle et al56

Mixed methods research

(Usability study)

60–76, M = 64.3 54% 57% Not reported. 28 Belgium Activator, a mobile self-monitoring tool designed to reduce older adults’ sedentary behavior Sedentary behavior change
Daly et al57

Quantitative research

(Pilot study)

65–81,

M = 70

50% 60% Not reported. 20 Australia PhysiApp, a tablet-based app that delivers tailored, home-based exercise programs for community-dwelling older adults Home-based exercises
Dekker-van Weering et al58

Quantitative research

(RCT)

65–75, M = 70.2 61.1% 8.3% Not reported. 36 The Netherlands A tablet or computer-based portal that provides home-based exercise programs for pre-frail older adults Physical activities
Delbaere et al59

Quantitative research

(RCT)

70+,

M = 77.4

67.4% Not reported. 85% (88.4%) in the intervention (control) group owned computers. 503 Australia StandingTall, a tablet-based mobile app that delivers home-based, balance exercises to older adults Balance exercises
Geerds et al60 Mixed methods research (Usability study) M = 80.5 71.80% Not reported. 93.8% had more than 5 years of smartphone experience. 48 The Netherlands A mobile app designed to monitor postoperative functional recovery after hip fracture Functional recovery after hip fracture
Geraedts et al61 Quantitative research (Feasibility study)

70+,

M = 81

62.5% Not reported. 62.5% had computer experience; 2.5% had a smartphone. 21 The Netherlands A tablet-based app that provides home-based exercise programs for pre-frail old adults Home-based exercises
Haeger et al62 Quantitative research (Feasibility study, controlled trial)

70+,

M = 76.5

50% Not reported. Not reported. 10 Germany MIT App Inventor 2, a mobile app that plans trips in hometowns to increase mobility in older adults Mobility
Harte et al63 Mixed methods research (Usability study)

61–85,

M: not reported.

Not reported. Not reported. Not reported. 12 Ireland A mobile app that integrates fall risk detection for older adults Fall risk detection and fall prevention
Hawley-Hague et al64 Qualitative research (Usability study, focus groups, interviews) 64–92, M = 77.1 Not reported. Not reported. Not reported. 7 United Kingdom Two mobile apps that support falls rehabilitation exercises (ie, My Activity Programme for patients, Motivate Me for professionals) Fall rehabilitation exercises
Hill et al65 Mixed methods research (Feasibility study)

60+,

M = 78.8

78% 56% Not reported. 9 United States A tablet-based attention training app designed to improve cognitive functioning in older adults Cognitive training
Hill et al66 Mixed methods research (Usability study)

60+,

M = 79

58% 50% Not reported. 12 United States A modified tablet-based attention training app designed to improve cognitive functioning in older adults Cognitive training
Hsieh et al67 Mixed methods research (Usability study)

70+,

M = 80.3

81.8% 27.2% 54.5% used tablets and 81.1% used smartphones. 11 United States Steady, a mobile app for fall risk screening for older adults Fall risk screening and prevention
Kang et al68

Quantitative research

(Pre-post experiment)

65–75,

M = 70

50% Not reported. Not reported. 4 South Korea A mobile app that provides exercise suggestions for older adults with chronic disorders Exercise suggestions
Kwan et al69

Quantitative research

(RCT)

60+, Median = 71 85.00% Not reported. Not reported. 33 Hong Kong Samsung Health, a mobile app that monitors walking behaviors Walking activities
Li et al70

Quantitative research

(Pre-post between-subjects experiment)

65+,

M = 71.3

70% Not reported. Not reported. 30 Singapore 5 exergames (ie, Skiing, Hiking, Pikkuli, Chinatown Race, RehaMed Volleyball) that promote physical activities in older adults Physical activities
Li et al71

Quantitative research

(RCT)

60+,

M = 79.3

19.4% 4.6 years on average Not reported. 31 Hong Kong Caspar Health e-system and a mobile app designed to provide occupational therapy rehabilitation for elderly outpatients after hip fraction surgery Physical and functional ability
Mehra et al72 Mixed methods research (Usability study)

69–99

M: not reported.

73.3% Not reported. Not reported. 15 The Netherlands VITAMIN app, a tablet-based app that supports older adults in home-based exercises Exercise training
Pettersson et al73 Qualitative research (Feasibility study)

70+,

M = 76

52.6% Not reported. 71% (72%) had access to tablet/smartphone (computer). 28 Sweden Safe Step, a mHealth app that supports self-managed exercises and behavior changes for older adults with impaired balance Self-managed exercises and behavior changes
Shake et al74

Quantitative research

(RCT)

65+,

M = 73.4

86% 20% Not reported. 105 United States Bingocize, a mobile game app designed to provide exercise and health education for older adults Exercises and health education
Silveria et al75

Quantitative research

(Pre-post intervention study)

65+,

M = 75.2

64% 54.% had trades or professional diploma 52.3% frequently used cellphones; 68.2% used computers; 59.1% used the Internet. 44 Switzerland ActiveLifestyle, a tablet-based app that delivers home-based strength-balance training to independently living older adults Strength-balance training
Tabak et al76 Mixed methods research

65–75,

M = 71

50% Not reported. 40% had daily technology use. 20 United States WordFit, a game-based mobile coaching app that stimulates daily physical activities among older adults Physical activities
Taylor et al77

Quantitative research

(Feasibility study)

60+,

M = 83

53.3% 11 years of education on average 33% owned a computer, 20% used a computer. 15 Australia StandingTall, a tablet-based app that delivers tailored exercise programs to elderly people with dementia Exercise programs
Van Het Reve et al78

Quantitative research

(Pre-post intervention study)

65+,

M = 75

63.6% 13.6% Not reported. 44 Switzerland ActiveLifestyle, a tablet-based app that delivers strength-balance training to independently living older adults Strength-balance training
Zhong and Rau79

Quantitative research

(Usability test, mixed design experiment)

60–90, M = 69.8 73% 18.9% 73.6% had a smartphone and 60.1% had Internet access. 148 China Pocket Gait, a mobile app designed to provide gait assessment and fall prevention for older adults Fall prevention
Social inclusion and well-being (N = 6)
Chi et al80

Mixed methods research

(Pilot study)

68–89,

M = 78.3

100% Not reported. 70% felt comfortable using technology. 10 United States Digital Pet, a tablet-based conversational agent in the form of an avatar for older adults Social connectedness
Goumopoulos et al81

Mixed methods research

(Pilot study)

60+,

M = 65.7

59% Not reported. Not reported. 22 Greece Senior App Suite, a mobile app designed to improve the social well-being and independence of senior people Social connectedness
Jansen-Kosterink et al82

Quantitative research

(Usability study)

60+,

M = 73.4

80% 41% 22%, 66%, and 12% of participants had positive, neutral, and negative attitudes toward technology. 91 The Netherlands GezelschApp, a mobile app that encourages social participation in community-dwelling older adults Social connectedness
Judges et al83 Mixed methods research 68–92, M = 80.6 70% Not reported. Most of them had no experience with computers. 10 Canada InTouch, a tablet-based communication app that reduces loneliness and social isolation in the elderly Social connectedness
Neves et al84] Mixed methods research (Feasibility study) 74–95, M = 82.5 66.7% Not reported. Digital literacy: 4 (no); 3 (low); 5 (medium). 12 Canada InTouch, a tablet-based communication app that reduces loneliness and social isolation in the elderly Social connectedness
Similä et al85 Mixed methods research (Feasibility study) 66–82, M = 73 100% Not reported. 5 participants had Internet access; 4 had used a computer in the previous year; 1 had used a smartphone or tablet. 7 Finland Oiva, a mobile app that provides mental wellness training for older adults Mental wellness training
Healthy dieting (N = 5)
Aure et al86 Qualitative research (Interviews) 68–95, M = 81 66.7% Not reported. 44.4% had experience with touch technology (eg, tablet, smartphone). 18 Norway Appetitus, a mobile nutrition app that supports weight gain or weight maintenance for older adults Self-monitoring of dieting
Aure et al87

Mixed methods research

(Feasibility study)

68–95,

M = 79.48

72% Not reported. 40% had experience using tablet or smartphone; 48% used the Internet daily, 16% used Internet weekly, and 36% never used Internet. 25 Norway Appetitus, a mobile nutrition app that supports weight gain or weight maintenance for older adults Self-monitoring of dieting
Farsjø and Moen88

Qualitative research

(Pilot study, focus group)

69–76

M: not reported.

100% Not reported. Not reported. 4 Norway APPETITT, a tablet-based app designed to prevent malnutrition and weight loss in the elderly Guidance for dieting
Franco et al89 Quantitative research (Usability study)

60–85

M: not reported.

79.60% 74.38% Not reported. 50 United Kingdom eNutri, a mobile app that provides graphical food frequency assessment for older adults Healthy dieting
Liu et al90

Quantitative research

(RCT)

60–90, M = 73.9 79% 58% 68% had used mobile phones or tablets; 7% had used nutrition-related apps. 57 Taiwan Two mobile apps (ie, voice-only reporting, voice-button reporting) for food intake reporting for elderly people Food intake reporting
Health monitoring and health concern reporting (N = 5)
Algilani et al91

Mixed methods research

(Feasibility study)

67–90,

M = 77

62.50% Not reported. Not reported. 8 Sweden A tablet-based app for early assessment and management of elderly patients’ reported concerns Health concern reporting
Göransson et al92 Qualitative research (Interviews)

65+,

M = 86

64.7% 23.5% Not reported. 17 Sweden A mobile app designed to report health concerns Health concern reporting
Göransson et al93 Quantitative research (Quasi-experimental study)

65+,

M = 86

64.7% 23.5% Not reported. 17 Sweden A mobile app designed to report health concerns Health concern reporting
Göransson et al94 Quantitative research (Quasi-experimental study)

65+,

M = 86

64.7% 23.5% Not reported. 17 Sweden A mobile app designed to report health concerns Health concern reporting
Quinn et al95 Quantitative research (Usability study)

65+,

M = 77.8

66.7% 100% 25% are skillful with technology and electronics. 12 United States A mobile app designed to improve engagement of the patient-informal caregiver team Health recording and monitoring
General (provides more than 1 type of functions) (N = 3)
Bott et al96 Quantitative research (Quasi-experiment)

65+,

M: Not reported.

54.7% 19% had less than high school education Not reported. 95 United States A tablet-based conversational agent (embodied in the form of an animated avatar) designed to provide psychosocial and health care support for hospitalized patients Social inclusion; delirium prevention; fall prevention
Stal et al97 Quantitative research (Within-subject experiment) 65+, M = 72.2 35% 50% Not reported. 20 The Netherlands A conversational agent, which is embedded in a frailty assessment app and provides training in healthy nutrition, physical health, cognitive health for older adults Healthy dieting; physical and cognitive function improvement
Steinert et al98 Quantitative research (Usability study) 61–76, M = 68 Not reported. Not reported. None of the participants had smartphone experience. 30 Germany MyTherapy, a mobile app that helps older adults achieve health-related goals Diverse health-related goals