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In vitro cytocompatibility evaluation of the MAO samples after culturing MC3T3-E1 pre-osteoblasts for a different period. (a) Cell viability, (b) cell proliferation, (c) ALP activities, (d) ECM mineralization, (e) collagen secretion and (f) the quantitative expression of ECM mineralization and collagen secretion * p < 0.05 and ** p < 0.01 versus the untreated control. Scale bar is 200 μm.
