Table 4.
Synergistic interaction between T. atlanticus essential oil (EO) and fluconazole against clinical pathogenic yeasts.
| Candida albicans | Candida glabrata | Candida krusei | Candida parapsilosis | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FIC | FICI | Gain | FIC | FICI | Gain | FIC | FICI | Gain | FIC | FICI | Gain | |
| EO | 0.25 | - | - | 0.25 | - | - | 0.25 | - | - | 0.25 | - | - |
| Fluconazole | 0.03 | 0.28 a | 32 | 0.03 | 0.28 a | 32 | 0.03 | 0.28 a | 32 | 0.00 | 0.25 a | 256 |
FIC: fractional inhibitory concentration. FICI: fractional inhibitor concentration index. FIC of oil = MIC of EO in combination with antibiotic/MIC of EO alone. FIC of antibiotic = MIC of antibiotic in combination with EO/MIC of antibiotic alone. FIC index = FIC of EO + FIC of antibiotic. a Total synergism.