Figure 2.

(A) The most influential parameters (with VIP larger than 1) affecting the CMC are the type of the BS, specifically the primary unconjugated and the secondary conjugated BS. (B) The primary unconjugated BS: cholic and chenodeoxycholic acids showed a positive impact on the creation of the micelles. The location of the OH group at positions 3α and 7α of NaCDC and 3α, 7α, and 12α of NaC promote micellar growth. The same orientation of the OH groups enhances the micelle formation. The location of the OH group and its position can be recognized as the most influential factor promoting micelle formation [3].