Cassileth 2003.

Study characteristics
Methods	RCT 2‐arm parallel‐group design
Participants	Adults with hematologic malignancy admitted for high dose therapy with autologous stem cell transplantation Diagnosis: Hodgkin's (n = 8, 12%), non‐Hodgkin's lymphoma (n = 31, 45%), myeloma/amyloidosis (n = 30, 43%) Total N randomized: 69 Total N analyzed: 60 N randomized to music group: 36 N randomized to control group: 33 N analyzed in music group: 34 N analyzed in control group: 26 Mean age: 52 years Sex: 37 (54%) females, 32 (46%) males Ethnicity: not provided Setting: inpatient Country: USA
Interventions	2 study groups: Music therapy group: live bedside music therapy provided by trained music therapist Control group: standard care Music selections provided: each music therapy session was individualized according to the needs of the participant. Number of sessions: the treatment group received a median of 5 sessions during a median of 10 days. Length of sessions: 20‐30 min Categorized as music therapy
Outcomes	Depression (POMS): post‐test scores (after 1 session) Anxiety (POMS): change scores (after 1 session) Mood (POMS total score): change scores (after 1 session) Fatigue (POMS): post‐test scores (after 1 session)
Notes	—
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "[R]andomized by telephone using the MSKCC clinical research database" (p. 2724) and "randomly permuted blocks with the following strata: whole body/whole lymphatic irradiation (yes/no); diagnosis (lymphoma, Hodgkin disease, myeloma/amyloidosis); and center (MSKCC/ICC)" (p. 2724).
Allocation concealment (selection bias)	Low risk	Quote: "[T]he use of telephone registration and randomization ensured concealment of treatment allocation".
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Music therapist and participants could not be blinded given the interactive nature of the music therapy session.
Blinding of outcome assessment (detection bias) Objective outcomes	Low risk	This study did not address objective outcomes.
Blinding of outcome assessment (detection bias) Subjective outcomes	High risk	Self‐report measures were used for subjective outcomes.
Incomplete outcome data (attrition bias) All outcomes	Low risk	Attrition rate = 9 (13%) Withdrew before learning allocation (n = 7); discharged before post‐test (n = 2)
Selective reporting (reporting bias)	Low risk	No evidence of selective reporting
Other bias	Low risk	Supported in part, by the Memorial Sloan‐Kettering Cancer Center Translational/Integrative Medicine Research Fund