FIG 5.
Capsule promotes transcytosis of other encapsulated pathogens. (A and B) Despite being outnumbered within the cells following (A) an invasion assay, (B) encapsulated S. pyogenes (GAS) escaped from within MCEC at higher rates than a nonencapsulated isogenic mutant (GAS Δcps). (D and E) Similar results were observed for S. aureus. (C) GAS resistance to H2O2-mediated killing in vitro was capsule dependent, whereas for (F) S. aureus, deletion of capsule had no effect. Each dot is a biological replicate. Errors bars represent the standard error of the mean. Statistical analyses: Mann-Whitney U-test. Asterisks denote statistical significance: ns, not significant; *, P < 0.05; **, P < 0.01.