TABLE 3.

Sensitivity and specificity of RT-QuIC in patients at the prodromal stage of α-synucleinopathy.

Substrate	α -Synucleinopathy	Number	Sensitivity (%)	Non-α -synucleinopathy	Number	Specificity (%)	References
CSF	Risk for PD (RBD)	3	0	See Table 1			Fairfoul et al., 2016
	iRBD	18	100	See Table 1			Rossi et al., 2020
	PAF	28	92.9
	Total iRBD	52	90.4	Total non-iRBD	51	92.2	Iranzo et al., 2021
	Disease free	20	80.0	Healthy control	40	90.0
	Converted to PD	16	93.8	Autosomal dominant AD	5	100
	Converted to DLB	16	100	Narcolepsy type 1	6	100
OM	iRBD	63	44.4	Healthy control	10	89.8	Stefani et al., 2021
	PD	41	46.3

iRBD, idiopathic/isolated rapid eye movement (REM) sleep behavior disorder; PAF, pure autonomic failure.