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Pharmacokinetic parameters of triptolide transdermal formulations (x̅ ± s, n = 5).
| PK parameters | Groups |
|
|---|---|---|
| TPCX cream | Triptolide cream | |
| AUC0−t, µg·(mL·h)−1 | 523.78 ± 54.24 | 227.20 ± 25.79 |
| AUC0−∞, µg·(mL·h)−1 | 686.22 ± 112.27 | 236.27 ± 39.17 |
| MRTlast, h | 7.41 ± 2.36 | 5.11 ± 0.66 |
| Cmax, µg·mL−1 | 1.35 ± 0.03 | 0.86 ± 0.13 |
| Tmax, h | 4.50 ± 0.02 | 5.38 ± 0.48 |
| t1/2, h | 6.06 ± 0.0.55 | 4.46 ± 0.71 |
