Table 2.
Outcomes for trajectories of ventilatory ratio and mechanical power in derivation cohort
| All (n=1007) |
Ventilatory ratio trajectories |
p value |
Mechanical power trajectories |
p value | ||||
|---|---|---|---|---|---|---|---|---|
| A (n=777) | B (n=230) | A (n=695) | B (n=312) | |||||
| Subphenotype 2 (%) | 336 (33%) | 190 (24%) | 146 (63%) | <0·001 | 118 (17%) | 218 (70%) | <0·001 | |
| Age, years | 63·7 (10·8) | 63·63 (10·94) | 63·89 (10·10) | 0·750 | 64·12 (10·53) | 62·72 (11·18) | 0·057 | |
| Male sex | 728 (72%) | 573 (74%) | 155 (67%) | 0·071 | 464 (66·8) | 264 (84·6) | <0·001 | |
| Body-mass index, kg/m2 | 28·6 (5·6) | 28·2 (4·3) | 29·9 (8·7) | <0·001 | 28·0 (4·3) | 29·9 (7·6) | <0·001 | |
| High positive end-expiratory pressure strategy | 269 (27%) | 211 (27%) | 58 (25%) | 0·510 | 158 (23%) | 111 (36%) | <0·001 | |
| Outcomes | ||||||||
| Acute kidney injury | 447 (44%) | 316 (41%) | 131 (57%) | <0·001 | 262 (38%) | 185 (59%) | <0·001 | |
| Renal replacement | 180 (18%) | 120 (15%) | 59 (26%) | 0·001 | 92 (13%) | 87 (28%) | <0·001 | |
| Venous thrombotic event | 285 (28%) | 195 (25%) | 90 (39%) | <0·001 | 180 (26%) | 105 (34%) | 0·014 | |
| ICU length of stay, days | 15 (9–27) | 15 (9–25) | 19 (10–32) | 0·007 | 15 (9–24) | 17 (9–31) | 0·063 | |
| Duration of invasive mechanical ventilation, days | 13 (8–23) | 13 (8–22) | 16 (8–26) | 0·008 | 13 (8–22) | 15 (8–25) | 0·039 | |
| Ventilator-free days and alive at day 28, days | 2 (0–16) | 6 (0–18) | 0 (0–9) | <0·001 | 7 (0–18) | 0 (0–9) | <0·001 | |
| Day 7 mortality | 112 (11%) | 74 (10%) | 38 (17%) | 0·011 | 60 (9%) | 52 (17%) | 0·001 | |
| Day 28 mortality | 294 (29%) | 210 (27%) | 84 (37%) | 0·018 | 173 (25%) | 121 (39%) | <0·001 | |
| Day 90 mortality | 349 (35%) | 242 (31%) | 104 (45%) | <0·001 | 212 (31%) | 134 (43%) | <0·001 | |
Data are n (%) or mean (SD). Trajectory A is a stable trajectory and trajectory B is an increasing trajectory.