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. 2021 Oct 6;48(6):210. doi: 10.3892/ijmm.2021.5043

Figure 5.

Figure 5

Effect of SETD7 on chondrocyte glycolysis. ATDC5 cells were pretreated with PFI-2 (40 nM) for 24 h to inhibit SETD7. (A) Glucose uptake and (B) lactic acid production increased after SETD7 was inhibited. (C) ECAR of control and PFI-2 groups. (D) mRNA expression levels of the key glycolysis enzymes GLUT1, LDHA, PGK1 and PKM2 of control and PFI-2 groups. ***P<0.001 vs. con. SETD7, SET domain containing 7; GLUT1, glucose transporter 1; LDHA, lactate dehydrogenase A; PGK1, phosphoglycerate kinase 1; PKM2, pyruvate kinase isoenzyme 2; ECAR, extracellular acidification rate; con, control; 2-DG, 2-deoxyglucose.