Figure 6.

Exosomal si-LOC100129516 suppresses atherosclerotic progression in vivo. (A) Reverse transcription-quantitative PCR was used to detect the levels of LOC100129516 in the aortic tissues of ApoE^−/− mice. (B) Hematoxylin and eosin staining as well as Oil-red O staining were used to observe aortic plaque formation in the ApoE^−/− mice. (C) ELISA kits were used to measure the levels of TC and LDL-C in the plasma of ApoE^−/− mice. n=6. ^**P<0.01 vs. control group; ^#P<0.01, ^##P<0.01 vs. AS group. siRNA, small interfering RNA; H&E, hematoxylin and eosin; TC, total cholesterol; LDL-C, low-density lipoprotein cholesterol; ctrl, control; AS, atherosclerosis; Exo, exosome.