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. Author manuscript; available in PMC: 2022 Aug 11.
Published in final edited form as: J Am Chem Soc. 2021 Jul 27;143(31):11939–11945. doi: 10.1021/jacs.1c05764

Scheme 4. Expanded scope using new coupling partners.a.

Scheme 4.

aYields are of purified product; diastereoselectivities determined by 1H NMR spectroscopy; 18-crown-6 added as 1M solution in THF. b>10:1 alkene E:Z ratios observed. cReaction performed at 60 °C. dCorresponding 4-phenylsulfonyl pyridine used as substrate. eArCN (1 equiv), organosilane (1.2 equiv) and acrylamide (1-2 equiv) used.