Table 1.
Patient characteristics as well as factors associated with the absence of lesions in excised conization tissues in patients who had undergone uterine cervical biopsies (N = 807).
| Characteristics | Group | N | Lesion in excision specimens, N (%) | P value | |
|---|---|---|---|---|---|
| Present | Absent | ||||
| Age (years) | ≤35 | 277 | 245 (88.4) | 32 (11.6) | 0.413 |
| >35 | 530 | 458 (86.4) | 72 (13.6) | ||
|
| |||||
| Menopause | Yes | 65 | 45 (69.2) | 20 (30.8) | <0.001 |
| No | 742 | 658 (88.7) | 84 (11.3) | ||
|
| |||||
| Referral cytology | NILM | 43 | 36 (83.7) | 7 (16.3) | 0.038 |
| ASCUS/LSIL | 377 | 323 (85.7) | 54 (14.3) | ||
| ASC-H/HSIL | 210 | 196 (93.3) | 14 (6.6) | ||
| Cancer | 7 | 6 (85.7) | 1 (14.3) | ||
|
| |||||
| Referral HPV DNA (N = 631) | Positive | 577 | 501 (86.8) | 76 (13.2) | 0.01 |
| Negative | 54 | 40 (74.0) | 14 (26.0) | ||
|
| |||||
| Punch biopsy | CIN1 | 43 | 34 (79.0) | 9 (20.9) | <0.01 |
| CIN2 | 259 | 206 (79.5) | 53 (20.5) | ||
| CIN3 | 504 | 462 (91.7) | 42 (8.3) | ||
|
| |||||
| Number of biopsies | <4 | 134 | 119 (88.8) | 15 (11.2) | 0.760 |
| 4 | 612 | 532 (86.9) | 80 (13.1) | ||
| >4 | 61 | 52 (85.2) | 9 (14.8) | ||
|
| |||||
| Colposcopy examination (N = 411) | Adequacy | 327 | 292 (89.3) | 35 (10.7) | 0.039 |
| Inadequacy | 84 | 68 (81.0) | 16 (19.0) | ||
|
| |||||
| Glandular involvement (N = 797) | Free | 418 | 348 (83.3) | 70 (16.7) | <0.01 |
| Involved | 379 | 347 (91.6) | 32 (8.4) | ||
|
| |||||
| Depth of conization | ≤18 mm | 333 | 279 (83.8) | 54 (16.2) | 0.022 |
| >18 mm | 468 | 418 (89.3) | 50 (10.7) | ||
|
| |||||
| Interval between biopsy and excision (months) | <1 | 428 | 370 (86.4) | 58 (13.6) | 0.918 |
| 1–2 | 153 | 134 (87.6) | 19 (12.4) | ||
| 2–3 | 29 | 24 (82.8) | 5 (17.2) | ||
| >3 | 30 | 26 (86.7) | 4 (13.3) | ||
|
| |||||
| Conization methods | CKC | 563 | 502 (89.2) | 61 (10.8) | 0.008 |
| LEEP | 243 | 200 (82.3) | 43 (17.7) | ||
CKC: cold knife conization; LEEP: loop electrosurgical excision procedure; CIN: cervical intraepithelial neoplasia; HPV: human papilloma virus; TCT: thin-prep test; ASCUS: atypical squamous cells; LSIL: low-grade squamous intraepithelial lesion; ASC-H: atypical squamous cells (cannot exclude high-grade squamous intraepithelial lesions); HSIL: high-grade squamous intraepithelial lesion; NILM: negative for intraepithelial lesion or malignancy.