Figure 2.

Bispecific and trispecific antibody targets in multiple myeloma. Filling color denotes functional class of the target antigen; filling intensity denotes stage of translational development: clinical (darker) or preclinical (lighter). NY-ESO-1 antigen is presented by MHC class I, which requires therapeutic antibody to recognize NY-ESO-1 in complex with patient-specific MHC-I allele. PD-1 has been targeted in combination with bispecific antibodies but is not itself a direct target of bispecifics.