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Three generations of adenoviral vectors and their applications
| Vector type | Deletion/s | Durability of transgene expression | Vector immunogenicity | Applications |
|---|---|---|---|---|
| First generation | E1; E3; E1&E3 | Short | High |
Vectored vaccines Oncolytic viruses |
| Second generation | E1; E3; E2a, E2b&E4 | Medium | Medium |
Gene therapy Vectored vaccines |
| Third generation | All Ad genes | Long | Low | Gene therapy |
Ad, adenoviral; E, early region.
