Table 2.

Univariable and multivariable Cox regression analyses for the prediction of progression-free survival in 1,096 patients with non-muscle-invasive bladder cancer

Progression free survival
Variable	Univariable			Multivariable
	HR	95% CI	p-value	HR	95% CI	p-value
Age	1.04	1.02–1.06	< 0.001	1.04	1.02–1.01	< 0.001
Gender
Male	Reference	Reference	Reference
Female	1.20	0.77–1.86	0.42
Pathologic T stage
pTa	Reference	Reference	Reference	Reference	Reference	Reference
pT1	1.57	1.06–2.32	0.02	0.48	0.23–0.99	0.050
Tumor grade
G1	Reference	Reference	Reference	Reference	Reference	Reference
G2	2.56	1.19–5.52	0.02	2.14	0.98–4.66	0.057
G3	3.92	1.87–8.22	< 0.001	6.04	2.21–16.50	< 0.001
Concomitant CIS	1.37	0.52–3.38	0.49	0.79	0.31–1.99	0.61
Tumor size
< 1 cm	Reference	Reference	Reference	Reference	Reference	Reference
1–3 cm	1.53	0.92–2.53	0.10	1.38	0.82–2.31	0.22
> 3 cm	1.80	1.08–3.01	0.025	1.40	0.82–2.37	0.22
Number of tumors
Single	Reference	Reference	Reference	Reference	Reference	Reference
2–7	1.50	0.96–2.35	0.08	1.23	0.78–1.95	0.38
≥ 8	2.61	1.49–4.55	0.001	2.19	1.24–3.88	0.007
Intravesical therapy	1.13	0.76–1.68	0.55	0.94	0.61–1.45	0.78
AGR
Normal	Reference	Reference	Reference	Reference	Reference	Reference
Low	1.99	1.35–2.94	0.001	1.81	1.22–2.68	0.003