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. 2021 Oct 12;12(10):930. doi: 10.1038/s41419-021-04185-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Colorectal tumor tissue and paired adjacent non-tumorous tissue samples were collected from 145 patients with CRC. A The mRNA level of FBXW11 in tissue specimens was measured by qRT-PCR. B The overall and disease-free survival of CRC patients with low or high FBXW11 expression was calculated using the Kaplan–Meier method. C The expressions of FBXW11 and ALDH1 in colorectal and adjacent non-tumorous tissue samples were detected by immunohistochemistry. Tissue samples with no staining (Normal, adjacent tissues), weak staining (Well), moderate staining (Moderate), and strong staining (Poor) were shown (×400 magnification). D The SI of each section was calculated by multiplying the immunohistochemical intensity score and the score of positively stained cells. An SI of ≤4 was defined as low expression, whereas an SI of ≥6 was considered high expression. The box plot shows the percentage of samples with low or high ALDH1 expression in tumors with low or high FBXW11 level. E Representative blots show the protein expressions of FBXW11 and ALDH1 in four pairs of tissue samples. Student’s t-test was used for statistical comparisons between the two groups.