Table 3.
HLA alleles, SNP and amino acids contained in the best models obtained from HPV(+)OPC analyses as judged by the BIC criterion.
| Model | Locus | OR (95%CI)a | P value | BIC | BIC difb | |
|---|---|---|---|---|---|---|
| A | rs4713462 + DRB1 (71-glu) | 4454 | 0 | |||
| rs4713462 | 0.67 (0.59-0.76) | 1.46 × 10−10 | ||||
| DRB1 (71-glu)c | 0.55 (0.46-0.67) | 1.03 × 10−9 | ||||
| B | rs4713462 + Class II Haplotype | 4465 | +11 | |||
| rs4713462 | 0.66 (0.58-0.75) | 5.52 × 10−11 | ||||
| DRB1*1301-DQA1*0103-DQB1*0603 | 0.45 (0.34-0.61) | 1.13 × 10−7 | ||||
| HLA-B*1501 + Class II Haplotype | 4489 | +35 | ||||
| HLA-B*1501 | 0.53 (0.40-0.71) | 1.77 × 10−05 | ||||
| DRB1*1301-DQA1*0103-DQB1*0603 | 0.43 (0.32–0.58) | 3.23 × 10−8 | ||||
| B (156) + Class II Haplotype | 4489 | +35 | ||||
| B (156) | 0.54 (0.41-0.71) | 1.53 × 10−05 | ||||
| DRB1*1301-DQA1*0103-DQB1*0603 | 0.43 (0.32–0.58) | 3.05 × 10−8 | ||||
BIC Bayesian information criterion, HLA human leukocyte antigen, OR odds ratio, 95% CI confidence interval
aObtained from multivariate logistic regression assuming an additive genetic model with sex and principal components as covariates.
bModels having their BIC difference within: +1–2 of the minimum have substantial support; +4–7 of the minimum have considerably less support; BIC > 10 above the minimum fail to explain some substantial structural variation in the data.
cAlleles where these amino acids are part of the sequence: 71(Glu) in DRB1*1301 and also in *0402, *1302, and *1102.