Table 4.

Top genome-wide significant regions and the highlighted ones in previous analysis from regional meta-analyses of OCC and HPV(-)OPC pooled analysis.

Genomic regions	Locus	SNP	Infoa	EA/OAb	Meta-analysisc
					OR (95%CI)	P value	Q_p
6p21.32	HLA region	rs3828805	0.88	T/C	0.77 (0.71–0.83)	2.5 × 10−9	0.71
		rs4713462	Genotyped	A/G	1.02 (0.95–1.10)	0.61	0.10
4q23	ADH1B	rs1229984	Genotyped	A/G	0.59 (0.49–0.71)	4.1 × 10−8	0.11
10q26	LHPP	rs201982221	Genotyped	D/I	1.74 (1.43–2.13)	4.8 × 10−8	0.28
12p23.3	BTBD11	rs35189640	0.94	T/C	1.79 (1.45–2.21)	7.5 × 10−8	0.54
15q21.2	FGF7	rs12910284	0.99	G/A	1.22 (1.14–1.30)	1.5 × 10−8	0.18

OR odds ratio, 95% CI confidence interval, Q_p Cochran’s heterogeneity p value.

^aImputation INFO (R2) is the average score across imputation batches.

^bEffect allele/other allele; “D” stands for deletion and “I” stands for insertion.

^cRegional meta-analyses Europe and North America with a total number of subjects: 2923 patients and 5256 controls.