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. 2021 Oct 12;12(10):936. doi: 10.1038/s41419-021-04233-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Representative image of PILO-induced epileptiform discharges in the acute stage and (b) representative image of spontaneous epileptiform discharges in the chronic stage. c Representative images of immunofluorescence staining demonstrating that in both the control group and epilepsy group, vezatin (green) was expressed in the hippocampal CA1 region, which was divided into three layers: the stratum oriens (so), pyramidal cell layer (pyr), and stratum radiatum (sr). Vezatin (green) was colocalized with the neuronal and dendritic marker MAP2 (red). d Statistical analysis of the MFI of vezatin in the three layers of the CA1 region (n = 6 per group; so, P = 0.043; pyr, P = 0.003; sr, P < 0.001). e Representative images of western blots showing hippocampal vezatin expression in the control (Con) group and epilepsy (Epi) group and (f) the corresponding statistical analysis (n = 6 per group, P < 0.001). Student’s t test; *P < 0.05, **P < 0.01, and ***P < 0.001.