Table 5:
Performance of the risk score for Ischemic stroke types using training and test dataset
| Training Dataset | Test Dataset | |||||||||||
| Cut off for the risk score | Se% | Sp% | PPV % | NPV % | K | Se% | Sp% | PPV % | NPV % | K | ||
| Constant weighting [10*β] | ≥ 8 | 99.7 | 1.5 | 50.3 | 82.4 | 0.012 | 100 | 0.9 | 50.2 | 100 | 0.009 | |
| ≥ 16 | 99.2 | 6.4 | 51.5 | 88.9 | 0.056 | 98.5 | 3.6 | 50.5 | 70.6 | 0.021 | ||
| ≥ 24 | 98.5 | 17.3 | 54.4 | 92.0 | 0.158 | 97.6 | 12.4 | 52.7 | 83.7 | 0.100 | ||
| ≥ 32 | 97.3 | 24.9 | 56.5 | 90.3 | 0.223 | 97.0 | 18.8 | 54.4 | 86.1 | 0.158 | ||
| ≥ 40 | 93.3 | 42.1 | 61.7 | 86.3 | 0.354 | 93.9 | 31.8 | 57.9 | 84.0 | 0.258 | ||
| ≥ 48 | 89.2 | 54.3 | 66.1 | 83.4 | 0.435 | 90.6 | 47.3 | 63.2 | 83.4 | 0.379 | ||
| ≥ 56 | 75.5 | 72.3 | 73.2 | 74.7 | 0.478 | 80.0 | 62.4 | 68.0 | 75.7 | 0.424 | ||
| ≥ 64 | 58.0 | 83.6 | 78.0 | 66.6 | 0.416 | 59.4 | 77.9 | 72.9 | 65.7 | 0.373 | ||
| ≥72 | 31.3 | 94.9 | 85.9 | 58.0 | 0.262 | 43.9 | 88.2 | 78.8 | 61.1 | 0.321 | ||
| ≥ 80 | 14.4 | 97.9 | 87.1 | 53.3 | 0.122 | 23.3 | 97.0 | 88.5 | 55.8 | 0.203 | ||
| ≥ 88 | 2.7 | 99.9 | 96.2 | 50.7 | 0.026 | 7.0 | 99.7 | 95.8 | 99.7 | 0.067 | ||
| ≥96 | 0.3 | 100 | 100 | 50.1 | 0.003 | 1.2 | 100 | 100 | 50.3 | 0.012 | ||
| AUC (95%CI): 0.81(0.80 – 0.82); p<0.001 | AUC (95%CI): 0.78(0.74 – 0.81); p<0.001 | |||||||||||
| Standardized weighting [10*βw] | Cut off for the risk score | Se% | Sp% | PPV % | NPV % | K | Se% | Sp% | PPV % | NPV % | K | |
| ≥ 8 | 99.7 | 1.5 | 50.3 | 82.4 | 0.012 | 100.0 | 0.9 | 50.2 | 100 | 0.009 | ||
| ≥ 16 | 98.9 | 10.5 | 52.5 | 90.8 | 0.095 | 98.5 | 7.6 | 51.6 | 83.3 | 0.061 | ||
| ≥ 24 | 98.5 | 17.4 | 54.4 | 92.1 | 0.159 | 97.6 | 12.4 | 52.7 | 83.7 | 0.100 | ||
| ≥ 32 | 97.8 | 23.8 | 56.2 | 91.4 | 0.215 | 97.0 | 19.7 | 54.7 | 86.7 | 0.167 | ||
| ≥ 40 | 93.4 | 41.4 | 61.5 | 86.3 | 0.349 | 93.9 | 33.9 | 58.7 | 84.8 | 0.279 | ||
| ≥ 48 | 87.5 | 58.6 | 67.9 | 82.4 | 0.461 | 90.0 | 48.5 | 63.6 | 82.9 | 0.385 | ||
| ≥ 56 | 77.6 | 71.9 | 73.4 | 76.3 | 0.495 | 81.5 | 63.9 | 69.3 | 77.6 | 0.455 | ||
| ≥ 64 | 60.7 | 82.5 | 77.6 | 67.7 | 0.432 | 58.2 | 78.8 | 73.3 | 65.3 | 0.370 | ||
| ≥72 | 38.3 | 93.2 | 84.9 | 60.2 | 0.314 | 38.8 | 89.7 | 79.0 | 59.4 | 0.285 | ||
| ≥ 80 | 16.1 | 97.7 | 87.2 | 53.8 | 0.137 | 22.7 | 97.3 | 89.3 | 55.7 | 0.200 | ||
| ≥ 88 | 4.3 | 99.7 | 93.0 | 51.0 | 0.040 | 4.8 | 99.7 | 94.1 | 51.2 | 0.045 | ||
| ≥96 | 0.3 | 50.1 | 100 | 50.0 | 0.003 | 0.6 | 100 | 100 | 50.2 | 0.006 | ||
| AUC (95%CI): 0.81(0.80–0.83); p<0.001 | AUC (95%CI): 0.78(0.74 – 0.81); p<0.001 | |||||||||||
Se-Sensitivity; Sp-Specificity; PPV-Positive Predictive Value; NPV-Negative Predictive Value; K-Cohen’s Kappa; AUC-Area Under the ROC; CI-Confidence Interval.