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. Author manuscript; available in PMC: 2022 Oct 11.
Published in final edited form as: Curr Biol. 2021 Aug 18;31(19):4305–4313.e5. doi: 10.1016/j.cub.2021.07.053

Figure 4: The development of ipsilateral eye cortical responses requires vision and is sensitive to monocular deprivation.

Figure 4:

(A) As in Figure 3A, but for normally reared (NR, n=4) and ipsilateral eye sutured (iMD, n=4) mice.

(B) Plot of the proportion of cells that respond to visual stimulation of the ipsilateral eye in P18 mice that were normally reared (NR, n=4), dark reared (DR, n=4), or that experienced monocular lid suture of the ipsilateral eye (iMD, n=4) from P14 to P18. Each point is from a single imaging plane. Mean and standard deviation are shown as black dots and lines. Mann-Whitney U test with Bonferroni correction. **, p<0.01; ***, p<0.001; ****, p<0.0001 after correction.

(C-E) Boxplots of measures of circular variance, spatial frequency preference, and complexity of neuron responses evoked by ipsilateral eye stimulation in NR (n=562 cells), DR (n=367 cells), and iMD (n=178 cells) mice. Black horizontal line, median; box, quartiles with whiskers extending to 2.698σ. Mann-Whitney U test with Bonferroni correction. *, p<0.05; **, p<0.01; ***, p<0.001; ****, p<0.0001 after correction.

(F-J) Same as in B-E, but for responses of neurons evoked via contralateral eye stimulation in NR (n=916 cells) and iMD (n=1104) mice. Note the quality of contralateral eye tuning is not affected by iMD.

See also Figure S6.