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. Author manuscript; available in PMC: 2022 Nov 15.
Published in final edited form as: Eur J Med Chem. 2021 Jul 30;224:113719. doi: 10.1016/j.ejmech.2021.113719

Table 3.

In vitro microsomal stabilities of compounds 7a, 7k, 12a, 12b, 19a, and 19b in liver microsomes from mice, rats, or humans

Compounds Metabolic stability in mouse Metabolic stability in rat Metabolic stability in human
t1/2 (h) Clint (μL/min/mg) t1/2 (h) Clint (μL/min/mg) t1/2 (h) Clint (μL/min/mg)
7a 0.8 27.8 1.0 22.6 1.9 12.0
7k 1.0 24.3 0.9 24.8 2.3 10.0
12a 0.7 35 1.3 18.0 1.3 17.5
12b 1.1 21.6 1.6 14.2 1.5 15.7
19a >4 5.5 2.5 9.2 >4 3.2
19b 1.2 19.9 0.6 36.7 1.4 16.3
Verapamil 0.1 192.5 0.2 100.4 0.3 85.6