Fig. 4.

Immune checkpoint expression is significantly associated with patient outcomes. Flow cytometry on peripheral blood mononuclear cells isolated from patient blood samples was used to assess the expression of various immune checkpoint molecules and associated proliferative markers on T cells. Those whose baseline levels (a) or change at later time points (b) were significantly associated with RECIST response are displayed. Survival curves illustrating immune checkpoint molecules and associated proliferative markers whose baseline levels (c) or change over time (d) were significantly associated with mPFS. C1D1 = cycle 1 day 1, C1D15 = cycle 1 day 15, C3D1 = cycle 3 day 1. Statistical significance determined with Fisher’s exact test (a, b), or the log-rank method (c, d)