Fig. 5.

The levels of various phenotypically defined immune cell populations are associated with patient outcomes. Flow cytometry was used to assess the presence of various phenotypically defined immune cell populations in peripheral blood mononuclear cells isolated from patient blood samples. Those whose baseline levels (a) or change throughout treatment (b) were significantly associated with RECIST response are displayed. Phenotypically defined immune cell populations whose levels are significantly different at baseline (c) when comparing responders to non-responders are illustrated. Survival curves for populations whose baseline levels (d) or change over time (e) were significantly associated with mPFS are displayed. C1D1 = cycle 1 day 1, C1D15 = cycle 1 day 15, C3D1 = cycle 3 day 1. Statistical comparisons made with Fisher’s exact test (a, b), unpaired student’s t test (c), or the log-rank method (d, e)