Table 4.
Univariate analysis of factors associated with new onset venous thromboembolism during NACT (N=233)
Patients at risk | New onset VTE | OR (95% CI) | p value | |
---|---|---|---|---|
All | 233 | 27 | ||
Age(years) | ||||
<70 | 126(54.1) | 19(70.4) | 0.45(0.19–1.09) | 0.99 |
≥70 | 107(59.9) | 8(29.6) | ||
Histology | ||||
Serous | 196(84.1) | 22(81.5) | 0.89(0.29–2.3) | 0.78 |
Non-Serous | 37(15.9) | 5(18.5) | ||
FIGO Stage | ||||
III | 71(30.6) | 3(11.1) | 3.9(1.2–13.6) | 0.03 |
IV | 161(69.4) | 24(88.9) | ||
Germline mutation | ||||
No mutation | 144(78.7) | 17(77.3) | 1.1(0.38–3.19) | 0.78 |
Positive for BRCA 1 or 2 | 33(21.1) | 5(22.7) | ||
Khorana Score | ||||
<2 | 103(44.2) | 11(40.7) | 1.17(0.5–2.7) | 0.84 |
≥2 | 130(55.8) | 16(59.3) | ||
Data are expressed as n (%) unless otherwise specified
NACT, neo-adjuvant chemotherapy; VTE, venous thromboembolism; OR, Odds ratio; FIGO, The International Federation of Gynecology and Obstetrics; BRCA, Breast Cancer gene