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. 2021 Oct 12;7:289. doi: 10.1038/s41420-021-00676-w

Fig. 1. Morphological and ultrastructural destruction of sciatic nerves in MPTP-induced mice.

Fig. 1

A Representative images of TH+ neurons in SNpc. Scale bar, 200 µm. B Toluidine blue staining showed degenerated myelin sheath and atrophied axons in sciatic nerves of MPTP group compared with saline group. Scale bar, 200 µm. C Electron micrographs of myelinated axons suggested that homogeneous SCs and axons were neatly arranged in sciatic nerves of saline group, with swollen myelin layer, fragmentized SCs and accumulated degenerative products in MPTP group. Scale bar, 2 µm. D Stereological quantitative analysis displayed decreased TH+ neurons in SNpc after MPTP exposure. Data were presented as mean ± SEM and analyzed by Student’s t-test; n = 6. **p < 0.01 vs. saline group. MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; TH, tyrosine hydroxylase; SNpc: substantia nigra pars compacta; SCs: Schwann cells; SEM: standard error of the mean.