Fig. 7. Motor dysfunction in MPTP-induced mice with improvement after CU-CPT22 preconditioning.

Mice were tested 3 days after the last MPTP administration. A Latency to fall off and Velocity before fall off in Rotarod test. B T-turn and T-LA in Pole test. C Total distance and Total velocity in Open-field test. Data were presented as mean ± SEM and analyzed by one-way ANOVA followed by Tukey’s post hoc test; n = 12. *p < 0.05, **p < 0.01 vs. saline group; ^#p < 0.05, ^##p < 0.01 vs. MPTP group. MPTP: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; T-turn: time to turn; T-LA: time to climb down; SEM: standard error of the mean; ANOVA: analysis of variance.