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. 2021 Oct 12;11:20219. doi: 10.1038/s41598-021-99507-2

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© The Author(s) 2021, corrected publication 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Grouping of patient response. (A–D) Estimated growth trajectories of representative patients for fitted HFSRT (red), and simulated iRT (blue) and iRT + boost (green) treatments with up to eleven treatment fractions. Shaded areas correspond to the envelope of the bootstrap estimated modeling uncertainty. (A) Group 1, (B) Group 2, (C) Group 3, (D) Group 4. (E) Analysis of the logarithm of the decay rate $ε$ for the different groups. Indicated p-values correspond to Wilcoxon signed rank tests between the groups comprising more than one patient. (F) Analysis of the radiotherapy surviving fraction for the different groups. There were no significant differences. In (E) and (F) median values (red lines), 25th and 75th percentiles (box upper and lower bounds) and full ranges (whiskers) are shown.