Table 1.
Characteristics of publications focused on OIT
| Publication | Study design | Participants (active group) | Food | Intervention | HRQoL form | Endpoints | Placebo arm | Conclusion |
|---|---|---|---|---|---|---|---|---|
| Anagnostou, 2014 42 | Randomized controlled trial (UK) | 39 children 7–16 years old | Peanut | OIT | FAQLQ-PF | FAQLQ-PF scores pre- and post-OIT | Yes | Both active and controls groups showed clinical meaningful improvement in FAQLQ-PF overall scores post treatment. |
| Blumchen, 2019 38 | Randomized controlled trial (Germany) | 20 children 3–17 years old | Peanut | OIT | FAQLQ-PF FAQLQ-CF |
HRQoL scores pre- and post-OIT | Yes | Significant improvement on both FAQLQ-PF and FAQLQ-CF in the active OIT group 10 weeks after final OFC, not in the placebo group. |
| Carraro, 2012 16 | Prospective cohort study (Italy) | 30 children 0–12 years old | Milk | OIT | FAQLQ-PF | FAQLQ-PF scores pre- and post-OIT | No | Significant improvement on FAQLQ-PF scores and in each domain 2 months after OIT in all age groups. |
| Dunn Galvin, 2018 11 | Randomized controlled trial (Ireland) | 20 children 2–11 years old | Peanut | OIT | FAQLQ-PF FAIM |
FAQLQ-PF and FAIM scores pre- and post-OIT | Yes | Significant improvement on FAQLQ-PF and FAIM scores 3 and 12 months after OIT. No change for FAQLQ-PF in the placebo group. Furthermore, significant improvement was reported from 3-month to 12-month post OIT. |
| Epstein-Rigbi, 2018 35 | Prospective cohort study (Israel) | 175 children 4–12 years old | Milk, peanut, egg, sesame, or tree nuts | OIT | FAQLQ-PF | FAQLQ-PF scores pre- and post-OIT | Yes (data not shown) | Significant improvement on FAQLQ-PF overall scores and each domain in the OIT group from the start to the end of treatment. No changes on HRQoL scores in the control group. |
| Otani, 2014 37 | Two phase I clinical trials (USA) | 40 children 4–16 years old | Peanut, walnut, cashew, pecan, milk, egg, sesame, almond, hazelnut | OIT | FAQLQ-PB | FAQLQ-PB scores pre- and post-OIT | Yes | Significant improvement on FAQLQ-PB scores in the active OIT groups at 6-month and 18-month follow-up. HRQoL scores in the control group significantly worsened at 6-month follow-up. No changes on HRQoL scores in the control group at 18-month follow-up. |
| Reier- Nilsen, 2019 17 | Randomized controlled trial (Norway) | 37 children 5–15 years old | Peanut | OIT | PedsQL 4.0 FAQLQ-PB |
HRQoL scores pre- and post-OIT | Yes | Significant improvement in children and parents after up-dosing and maintenance phases in both OIT and control groups. The change in HRQoL was significantly different from the controls for the parental proxy-reports only |