. Author manuscript; available in PMC: 2022 Oct 1.

Published in final edited form as: J Allergy Clin Immunol Pract. 2021 Jun 2;9(10):3705–3714. doi: 10.1016/j.jaip.2021.05.020

Table 2.

Characteristics of publications focused on food challenge

Publication	Study design	Participants (active group)	Food	Intervention	HRQoL form	Endpoints	Placebo arm	Conclusion
Dunn Galvin, 2010 ¹⁸	Prospective cohort study (Ireland)	82 children 0–12 years old	Peanut, nut, milk, egg, fish/shellfish	OFC	FAQLQ-PF FAIM	FAQLQ-PF and FAIM scores pre- and post-OFC	No	Significant improvement in FAQLQ-PF total scores and each domain and FAIM 6 months after OFC.
Hourihane, 2017 ⁴³	Prospective cohort study (Ireland, Australia, US)	378 children 1–18 years old	Peanut	OFC	FAQLQ-PF FAQLQ-CF	FAQLQ-PF and CF scores pre- and post- OFC	No	Significant improvement in FAQLQ-PF and CF 1 month after the single-dose OFC, irrespective of the OFC outcome.
Knibb, 2012 ⁴⁰	Prospective cohort study (UK)	31 children 6–16 years old	Peanut, tree nut	OFC	FAQLQ-PB FA-specific HRQoL by Avery PredsQL 4.0	HRQoL scores for children and parents pre- and post- OFC	Yes	Significant improvement of related-food HRQoL in children and mother 3–6 months following OFC. No improvement in the control group.
Soller, 2014 ⁴⁴	Prospective cohort study (Ireland)	54 children 0–12 years old	Peanut, tree nut, milk, egg, wheat, sesame	OFC	FAQLQ-PF	FAQLQ-PF scores pre- and post- OFC	No	FAHRQoL improved significantly from 2 months prechallenge to 2 months postchallenge for both groups, but began to decrease at 6 months postchallenge in allergic patients.
van der Valk, 2016 ³⁹	Prospective cohort study (Netherlands)	84 parents 33 children 2–17 years old 26 teanagers	Cachew	DBPCFC	FAQLQ-PF FAQLQ-CF FAQLQ-TF FAIM	HRQoL scores pre- and post- DBPCFC for each age group	No	No significant improment in FAQLQ-PF, FAQLQ-CF and FAQLQ-TF total and domain scores 6 months after the OFC compared to baseline.
van der Velde, 2012 ⁴⁵	Prospective cohort study (Netherlands)	53 adults ≥18 years old; 46 adolescents 13–17 years old; 57 children 8–12 years old	peanut, nut, milk, egg, wheat, soy, sesame	DBPCFC	FAQLQ-AF FAQLQ-TF FAQLQ-CF FAIM	HRQoL scores pre- and post- DBPCFC for each age group	Yes	Significant improvement in FAQLQ-AF and FAQLQ-CF in OFC group 6 months after challenge, irrespective of the OFC outcome. Significant improvement was found in FAQLQ-TF in participants with negative OFC outcome, and in the control group.