Fig. 1.

Targeting of MYC. Illustrated are options of direct or indirect MYC inhibition by pharmacological inhibitors or activators, respectively. Indirect inhibition is achieved by interfering with transcription, translation. The concept to target MYC by synthetic lethality in PDAC is shown. Direct inhibition by a synthetic OMOMYC peptide or possibly by PROTACs renders the MYC protein itself nonfunctional. SE Super enhancer, BRD Bromodomain proteins