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Promising drug targets from experimental studies. Multiple signaling pathways are involved in the hepatocarcinogenesis, among which the HGF/MET, FGF/FGFR, PI3K/AKT/mTOR, and CDK4/6 signaling pathways hold the promises as effective targets for HCC treatment. Targeted drugs showing efficacious anti-tumor effects from the preclinical studies are shown and summarized in the figure. Normal arrows: activation; blunted arrows: inhibition.
