Skip to main content
. 2021 Apr 13;71(5):961–973. doi: 10.1136/gutjnl-2020-322595

Figure 3.

Figure 3

Kaplan-Meier curves comparing relapse-free survival (RFS) after surgical resection for patients with NF-PanNETs. (A) No statistically significant differences in RFS were identified between patients with NF-PanNETs (n=561) that were classified into four immunophenotypic groups: ARX-positive/PDX1-negative (ARX+), ARX-negative/PDX1-positive (PDX+), ARX-positive/PDX1-positive (DP) and ARX-negative/PDX1-negative (DN). (B) Similarly, no RFS difference was seen between patients with ARX++DN NF-PanNETs and patients with PDX1++DP NF-PanNETs. however (C) the RFS for patients with ALT-positive NF-PanNETs was significantly shorter than patients with ALT-negative NF-PanNETs. In addition, (D) the combination of ALT status and the immunophenotypic subgroups, ARX++DN and PDX1++DP, did not demonstrate any prognostic benefit over ALT status alone. ALT, alternative lengthening of telomeres; ARX, aristaless-related homeobox gene; NF-PanNETs, non-functional pancreatic neuroendocrine tumours; PDX1, pancreatic and duodenal homeobox 1.