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. 2021 Sep 29;12:688961. doi: 10.3389/fimmu.2021.688961

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Copyright © 2021 Shao, Wang, Yuan, Jin, Chen and Wu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Glycometabolism of TIGIT⁺CD3⁺ T cells is decreased in colorectal cancer patients. TIGIT⁺CD3⁺ T cells were sorted from PBMC of colorectal cancer patients. (A) The concentration of 2-DG6P, Lactate and Pyruvate was reduced in TIGIT⁺CD3⁺ T cells compared to TIGIT^-CD3⁺ T cells. (B) Glut1, HK1, HK2, and PFK were measured by RT-PCR and mRNA expression was quantified. Glut1, HK1, HK2, and PFK elevated in TIGIT⁺CD3⁺ T cells. (C) Representative blots of western blotting were shown. (D) Western blotting analysis was performed to determine the phosphorylation levels of the AKT/mTOR pathway. The results were normalized to GAPDH expression and presented as relative protein expression. *P < 0.05; **P < 0.01.