Table 3.
Rankings of adjunctive aripiprazole, metformin and PGD in reducing prolactin levels in schizophrenia.
| Outcomes | APs (number of studies) | Treatment | SUCRA (%) | PrBest (%) | Mean Rank |
|---|---|---|---|---|---|
| Prolactin level changes | All (n = 62) | Ari < 5 mg/d | 78.8 | 56.3 | 2.7 |
| Ari > 10 mg/d | 90.3 | 36.5 | 1.8 | ||
| Ari = 5 mg/d | 73.6 | 1.7 | 3.1 | ||
| PGD > 1:1 | 58.3 | 1.6 | 4.3 | ||
| PGD = 1:1 | 58.0 | 4.0 | 4.4 | ||
| 5 mg/d < Ari ≤ 10 mg/d | 48.1 | 0.0 | 5.2 | ||
| Metformin <1,000 mg/d | 27.0 | 0.0 | 6.8 | ||
| Metformin <1,000 mg/d | 8.7 | 0.0 | 8.3 | ||
| Placebo | 7.2 | 0.0 | 8.4 | ||
| Risperidone (n = 22) | PGD = 1:1 | 81.0 | 31.2 | 2.5 | |
| Ari = 20 mg/d | 80.4 | 18.8 | 2.6 | ||
| PGD = 2:1 | 78.0 | 24.4 | 2.8 | ||
| Ari = 15 mg/d | 59.2 | 25.4 | 4.3 | ||
| Ari = 10 mg/d | 56.7 | 0.2 | 4.5 | ||
| Ari = 5 mg/d | 48.6 | 0.0 | 5.1 | ||
| Metformin <1,000 mg/d | 15.4 | 0.0 | 7.8 | ||
| Metformin <1,000 mg/d | 15.4 | 0.0 | 7.8 | ||
| Placebo | 15.4 | 0.0 | 7.8 | ||
| Amisulpride (n = 8) | Ari < 5 mg/d | 89.1 | 78.7 | 1.7 | |
| Ari = 5 mg/d | 86.2 | 20.5 | 1.8 | ||
| Metformin <1,000 mg/d | 58.1 | 0.1 | 3.5 | ||
| PGD > 1:1 | 48.0 | 0.5 | 4.1 | ||
| 5 mg/d < Ari ≤ 10 mg/d | 44.9 | 0.2 | 4.3 | ||
| Ari > 10 mg/d | 20.5 | 0.0 | 5.8 | ||
| Placebo | 3.2 | 0.0 | 6.8 | ||
| Olanzapine (n = 7) | Arinzapine | 98.3 | 94.9 | 1.1 | |
| PGD = 1:1 | 61.2 | 5.1 | 2.2 | ||
| Ari <10 mg/d | 39.2 | 0.0 | 2.8 | ||
| Placebo | 1.2 | 0.0 | 4.0 | ||
| PANSS total score changes | All (n = 41) | Metformin < 1,000 mg/d | 71.3 | 42.7 | 3.0 |
| PGD = 1:1 | 53.3 | 24.3 | 4.3 | ||
| PGD > 1:1 | 52.9 | 9.9 | 4.3 | ||
| Ari > 10 mg/d | 51.6 | 6.2 | 4.4 | ||
| Ari <5 mg/d | 48.6 | 14.8 | 4.6 | ||
| 5 mg/d < Ari ≤ 10 mg/d | 46.1 | 1.6 | 4.8 | ||
| Ari = 5 mg/d | 41.4 | 0.4 | 5.1 | ||
| Placebo | 34.9 | 0.0 | 5.6 | ||
| Risperidone (n = 13) | Ari > 10 mg/d | 61.7 | 25.7 | 2.9 | |
| 5 < Ari ≤ 10 mg/d | 65.2 | 25.6 | 2.7 | ||
| PGD > 1:1 | 46.3 | 22.4 | 3.7 | ||
| PGD = 1:1 | 44.7 | 21.3 | 3.8 | ||
| Ari = 5 mg/d | 44.1 | 3.4 | 3.8 | ||
| Placebo | 37.9 | 1.7 | 4.1 | ||
| Amisulpride (n = 7) | Ari < 5 mg/d | 58.1 | 27.1 | 3.5 | |
| Ari = 5 mg/d | 64.3 | 16.1 | 3.1 | ||
| PGD > 1:1 | 53.6 | 9.3 | 3.8 | ||
| Metformin <1,000 mg/d | 49.2 | 17.8 | 4.0 | ||
| 5 mg/d < Ari ≤ 10 mg/d | 47.9 | 15.8 | 4.1 | ||
| Ari > 10 mg/d | 43.6 | 13.7 | 4.4 | ||
| Placebo | 33.5 | 0.2 | 5.0 |
Values in bold are those ranked the first. Ari, aripiprazole; PANSS, Positive and Negative Syndrome Scale; PGD, paeoniae-glycyrrhizae decoction; PrBest, the best probability; SUCRA, Surface under the cumulative ranking curve; Aps, antipsychotics.