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. 2021 Sep 29;12:718953. doi: 10.3389/fpsyt.2021.718953

Figure 1.

Figure 1

Acute but not chronic administration of the mGluR5 NAM CTEP ameliorates audiogenic seizures in Fmr1-KO mice. (A) Schematic shows acute CTEP dose schedule and AGS experimental design. (B) Fmr1-KO mice treated with vehicle exhibit increased susceptibility to audiogenic seizures compared to WT treated with vehicle (two-tailed Fisher’s exact test: p = 0.0001) and an acute dose of 2 mg/kg CTEP significantly reduced AGS incidence in Fmr1-KO mice (two-tailed Fisher’s exact test: p = 0.0038). (C) Schematic shows chronic CTEP dose schedule and AGS experimental design. (D) Chronic treatment (3 doses over 5 days) with 2 mg/kg CTEP no longer alleviates susceptibility to audiogenic seizures, indicating the development of acquired treatment resistance (Two-tailed Fisher’s exact test: Fmr1-KO vehicle treated vs. CTEP treated: p = 1.0). Data re-plotted from (32).