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. 2021 Sep 29;12:718953. doi: 10.3389/fpsyt.2021.718953

Figure 2.

Figure 2

Acute cycloheximide treatment ameliorates audiogenic seizures in Fmr1-KO mice and overcomes acquired CTEP resistance. (A) Schematic shows acute CHX dose schedule and AGS experimental design. (B) Acute treatment with 120 mg/kg CHX significantly reduced AGS incidence in Fmr1-KO mice (Two-tailed Fisher’s exact test: p = 0.0069). (C) Schematic shows acute cycloheximide after chronic CTEP dose schedule and AGS experimental design. (D) Chronic CTEP (3 doses of 2 mg/kg over 5 days) causes treatment resistance that can be overcome by an acute injection of 120 mg/kg CHX immediately prior to assessing AGS (Two-tailed Fisher’s exact test: Fmr1-KO 4x vehicle vs. Fmr1-KO 3x CTEP + CHX: p = 0.0131; Fmr1-KO 3x CTEP + vehicle vs. Fmr1-KO 3x CTEP + CHX: p = 0.0131).