Figure 3.

Myeloid-specific Pfkfb3 deficiency protects mice from LPS-induced cardiac dysfunction. (A) Representative M-mode echocardiograms of Pfkfb3^WT mice and Pfkfb3^ΔMϕ mice 6 h after LPS injection. (B-E) Quantification of ejection fraction (B), fractional shortening (C), left ventricle stroke volume (D), and cardiac output (E) of Pfkfb3^WT mice and Pfkfb3^ΔMϕ mice 6 h after LPS injection (n = 5). (F–H) Systolic blood pressure (F), diastolic blood pressure (G), and mean blood pressure (H) of Pfkfb3^WT mice and Pfkfb3^ΔMϕ mice before and after LPS injection (n = 8). All data are represented as mean ± SEM, *P < 0.05, **P < 0.01 and ***P < 0.001 for Pfkfb3^WT vs. Pfkfb3^ΔMϕ (unpaired two-tailed Student's t test).