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. 2021 Sep 29;15:736786. doi: 10.3389/fnins.2021.736786

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Copyright © 2021 Tikhonova, Amstislavskaya, Ho, Akopyan, Tenditnik, Ovsyukova, Bashirzade, Dubrovina and Aftanas.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of the CEF and Aβ25–35 administration (AD model) on spatial memory and learning in mice in the Barnes test. (A) Episodic memory and learning were evaluated by the latency (s) to find an escape box during the first day of training. (B) General exploratory activity was estimated by the total number of nosepokes on the test day. (C) Long-term spatial memory was evaluated by the percentage of nosepokes to the target hole on the test day. The data are expressed as mean ± SEM of the values obtained in an independent group of animals (n = 7–15 per group). Statistically significant differences: ^&p < 0.05, ^&&p < 0.01, ^&&&p < 0.001 compared with values of the same group on the first training session; ^#p < 0.05 compared with respective values of the “Aβ + saline” group.