TABLE 1.
Effects of the CEF and Aβ25–35 administration (AD model) on the behavior of mice in the open field test.
| Index | Group | Effects (F, p) | |||
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| H2O + saline | H2O + CEF | Aβ25–35 + saline | Aβ25–35 + CEF | ||
| Locomotor activity (path length, cm) | 2728.0 ± 106.2 | 3224.7 ± 223.2* | 2668.2 ± 157.9 | 2580.5 ± 184.9$ | Aβ: F(1,37) = 4.4, p < 0.05; CEF: F(1,37) = 1.5, p > 0.05; Aβ × CEF: F(1,37) = 3.0, p > 0.05 |
| Exploratory activity (no. of rearings) | 65.9 ± 3.9 | 63.5 ± 5.5 | 60.1 ± 5.3 | 58.4 ± 7.0 | Aβ: F(1,37) < 1; CEF: F(1,37) < 1; Aβ × CEF: F(1,37) < 1 |
| Anxiety (time in the center, s) | 31.8 ± 4.1 | 34.1 ± 7.7 | 26.9 ± 3.7 | 21.9 ± 2.7 | Aβ: F(1,37) = 3.1, p > 0.05; CEF: F(1,37) < 1; Aβ × CEF: F(1,37) < 1 |
| Emotionality (no. of fecal boluses) | 1.40 ± 0.48 | 1.17 ± 0.65 | 2.08 ± 0.59 | 2.14 ± 0.51 | Aβ: F(1,37) = 1.8, p > 0.05; CEF: F(1,37) < 1; Aβ × CEF: F(1,37) < 1 |
Data are presented as mean ± SEM of the values obtained in an independent group of animals (n = 7–15 per group). Statistically significant differences: *p < 0.05 vs. the “H2O + saline” group; $ p < 0.05 vs. the “H2O + CEF” group.