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. 2021 Sep 29;12:706027. doi: 10.3389/fimmu.2021.706027

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Copyright © 2021 Hua, Ge, Zhang, Mo, Zhang, Zhang, Yang, Tai, Chen, Zhang and Liang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Blocking CXCR3 ameliorates EAP severity through inhibiting infiltration of macrophages to prostate. (A) CXCR3 inhibitors (AMG487) ameliorate the inflammation for EAP mice. (B) The histopathological scores for the AMG487 and vehicle groups. (C) Pain response test for the AMG487 and vehicle groups. (D, E) The results of flow cytometry for macrophages in the prostate of the AMG487 and vehicle groups. (F) Representative photographs of immunofluorescence staining of CXCR3 and macrophage markers in the prostate of the AMG487 and vehicle groups. Cells were stained for CD11b (red) and CXCR3 (green). The number of CD11b+CXCR3+ cells in the prostate of the AMG487 and vehicle groups was counted (G). Data are shown as mean ± SD by unpaired, two-tailed Student’s t-test analysis. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.