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. 2021 Sep;10(9):3669–3683. doi: 10.21037/tau-21-777

Figure 7.

Figure 7

Effect of miR-124-calpain small subunit 1 (CANP4)-CCR4-NOT transcription complex subunit 3 (CNOT3) on the cisplatin-resistance of 786-O cells in vivo. (A) Images of xenograft tumors formation from miR-124-overexpressed 786-O cells with or without CAPN4 and/or CNOT3. (B) The average volume of tumors is shown as mean ± SEM (standard error of mean). (C) Tumors from indicated xenograft mice were weighed immediately after removal and the average tumor weight is indicated as mean ± SEM. (D) A schematic model of cisplatin-induced miR-124 expression and its underlying mechanism in cisplatin resistance in RCC. *, P<0.05 vs. miR-124 group; #, P<0.05 vs. miR-124+CAPN4 group.