Table 2.
Evolution between first and second rehabilitation assessments.
| First assessment | Second assessment | p-value | ||
|---|---|---|---|---|
| Symptoms; n | 25 | |||
| Dyspnoea (modified MRC scale) | 2 ± 1 | 1 ± 1 | <.001 | |
| Dyspnoea (modified MRC ≥ 1); no.(%) | 22(88%) | 13(52%) | 0.007 | |
| Fatigue; no.(%) | 19(76%) | 15(60%) | 0.133 | |
| Chest pain; no.(%) | 13(52%) | 10(40%) | 0.371 | |
| Headache; no.(%) | 9(36%) | 9(36%) | 1 | |
| Muscular or articular pain; no.(%) | 10(40%) | 9(36%) | 1 | |
| Cough; no.(%) | 8(32%) | 5(20%) | 0.449 | |
| Lung function; n | 22 | |||
| FVC (% pred.) | 97 ± 17 | 104 ± 22 | 0.006 | |
| FEV1 (% pred.) | 96 ± 17 | 101 ± 23 | 0.052 | |
| FEV1/FVC (%) | 82 ± 9 | 80 ± 8 | 0.290 | |
| Functional assessment; n | 22 | |||
| 6-MWT distance (m) | 510 ± 89 | 569 ± 98 | <.001 | |
| 6-MWT distance (% pred.) | 83 ± 19 | 93 ± 18 | <.001 | |
| 6-MWT dyspnoea at rest (modified Börg scale) | 1 ± 2 | 1 ± 1 | 0.305 | |
| 6-MWT end-test dyspnoea (modified Börg scale) | 6 ± 2 | 5 ± 3 | 0.104 | |
| 6-MWT SpO2 at rest (%) | 98 ± 1 | 98 ± 1 | 0.042 | |
| 6-MWT SpO2 min (%) | 96 ± 2 | 96 ± 2 | 0.110 | |
| 3 min sit-to-stand test (n rep.) | 61 ± 30 | 80 ± 29 | <.001 | |
| Hyperventilation syndrome | 20 | |||
| Nijmegen score* | 27 ± 10 | 24 ± 11 | 0.709 | |
| Nijmegen >22; no.(%) | 11(55%) | 10(50%) | 1 | |
| Provocation test >5min; no. (%) | 17(89%) | 5(25%) | 0.001 | |
| Nijmegen >22 and Provocation test >5min; no.(%) | 10(50%) | 3(15%) | 0.023 | |
| Hospital Anxiety and Depression; n | 17 | |||
| Anxiety scorea | 8 ± 3 | 8 ± 0 | 0.941 | |
| Anxiety >7; no.(%) | 8(47%) | 10(59%) | 0.683 | |
| Depression scorea | 6 ± 4 | 5 ± 0 | 0.306 | |
| Depression >7; no.(%) | 6(35%) | 5(29%) | 1 | |
| Quality of life (VQ-11 questionnaire); n | 21 | |||
| Total scoreb | 29 ± 10 | 25 ± 10 | 0.041 | |
| VQ-11 > 21; no.(%) | 15(71%) | 12(57%) | 0.789 | |
| Functional dimension | 10 ± 3 | 8 ± 3 | <.001 | |
| Relational dimension | 9 ± 4 | 8 ± 4 | 0.162 | |
| Psychological dimension | 11 ± 4 | 10 ± 4 | 0.264 | |
FVC: forced vital capacity; FEV1: forced expiratory volume in 1 s; 6-MWT: 6-min walking test; SpO2: pulsed oxygen saturation. PCR+: positive SARS-CoV-2 Polymerase Chain Reaction test.
Duration between first and second assessments was 61 ± 20 days.
* Nijmegen score is considered positive when >22.
a
Anxiety or depression components of the HAD are considered positive when >7.
b
VQ-11 is considered altered when >21.